Preheat your oven to 350°F (175°C).

Cook the elbow macaroni according to package instructions until al dente. Drain and set aside.

In a large saucepan, melt the butter over medium heat. Once melted, whisk in the flour and cook for about 1 minute, stirring constantly.

Gradually add the whole milk, whisking continuously to avoid lumps. Cook until the mixture thickens and bubbles, about 5-7 minutes.

Stir in the Dijon mustard, garlic powder, onion powder, cayenne pepper, salt, and black pepper.

Remove the saucepan from heat and add the shredded cheddar and mozzarella cheeses, stirring until melted and smooth.

Combine the cooked macaroni with the cheese sauce, mixing well to coat all the pasta.

Pour the mac and cheese into a greased 9x13-inch baking dish.

In a small bowl, mix the breadcrumbs with the grated Parmesan cheese. Sprinkle this mixture evenly over the mac and cheese.

Bake in the preheated oven for 25-30 minutes, or until the top is golden brown and crispy.

Let it cool for a few minutes before serving.